esophagus cancer studies indicate a ratio between frequency of reflux symptoms and risk of adenocarcinoma. The constant acid reflux will irritate the lining of the esophagus, and complications can occur, such as Barrett's esophagus. Individuals with Barrett's esophagus are at an increased risk of developing adenocarcinoma. Barrett's esophagus is a condition in which the lining of the esophagus is replaced by tissue that is similar to that which is normally found in the stomach and intestine. The process of this change is called intestinal metaplasis. Individuals with Barrett's esophagus are about 40 times more likely to develop esophageal cancer than individuals in the general population.

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